The term" Menopause” was first invented in 1821 by French physician Dr. Charles Negrier, who described women’s complaints of depression, hot flashes and irregular periods. In Paris, France, in 1976, the first International Congress on Menopause was organized. Various countries have formed national societies on menopause. Symptomatology of menopause differs in different areas of the world, e.g. In the West - hot flush, and in Japan, shoulder pain is the symptom of menopause. Statistical analysis showed the mean age at menopause to be between 49 and 51. A combination of low steroids and high gonadotropins was the signature of menopause. There's an epidemiological finding that women who smoke may have earlier menopause because smoking may kill follicles or affect a woman endocrinologically. The menopausal transition most often begins between ages 45 and 55. It usually lasts about seven years but can last as long as 14. The duration can depend on lifestyle factors such as smoking, the age at which it begins, and race and ethnicity.